Modified Screen Printed Electrode for Electrochemical Determination of Carvacrol

In the present work, a fast electrochemical sensor for determination of carvacrol was developed based on Co3O4 nanoparticles modified screen printed electrode. Carvacrol could be determined directly by electrochemical oxidization with the modified electrode. Co3O4 nanoparticles increased electrochemical response to carvacrol. Experimental variables, such as the deposited amount of the modifier suspension, pH of the supporting electrolyte and the potential scan rate were optimized by monitoring the electrochemical responses of carvacrol. Under the optimum conditions, the modified electrode showed a wide linear dynamic range of 10.0–500.0 μM with a detection limit of 1.5 μM for the voltammetric determination of carvacrol. The prepared modified electrode showed high sensitivity, stability and good reproducibility in response to carvacrol, confirming its usability for the accurate determination of trace amounts of carvacrol in pharmaceutical and clinical preparations.