An efficient synthesis of diarylmethylamine by copper catalysts

Amines are important building blocks of pharmaceutical and agrochemical compounds which are also used as ligand and base in organic reactions [1].This type of structure is of interest for preparing natural product, bioorganic and drugs that can mention as cetirizine (antihistaminic) to treat allergic, sertraline and tianeptine (anti-depression), letrozole (treat cancer) and many other medications [2,3]. Arylation of activated aldimines is a superior route for the synthesis of α-arylmethylamines. Due to the application of these compounds, the use of various transition metal catalysts, substrates and aryl donor groups have been developed to improve the catalytic activity, scope of substrates and other variables. However some of these methods were used toxic and expensive reagents [4]. Herein we have designed an arylation reaction on imines to synthesis of aryl amines. A wide range of aryl amines were afforded by addition of aryl boronic acid to different aldimines in presence of non-expensive copper metal and phosphine ligands. The desired products were produced in good yield and were characterized by IR, 1HNMR and 13CNMR.