Synthesis and Surface Modification of NMOF for its Applications in Biomedicine

Metal–organic frameworks (MOFs) have fascinated great kindness from chemists due to their fantastic potential applications in catalysis, microelectronics, ion exchange, nonlinear optics, and gas storage [1]. Moreover, MOFs can be considered as good candidates for drug delivery systems due to below reason [2]: Firstly, the facile synthesis of NMOFs with different compositions, shapes, sizes, and chemical properties allowing that NMOFs are compositionally and structurally various. Secondly, the presence of relatively labile metal ligand bonds triggered that NMOFs are biodegradable. The important issues are stability and surface modification of NMOFs that should be discussed with respect to the biological application of NMOFs. By selecting different metal ions, organic linkers, and crystalline structures can be reached to differences in degradability; thus, a few hours to several weeks could be attuned for their degradation time [3]. We have studied that NMOF coated by silica in order to protect from rapid degradability, then release of drug and cytotoxicity of NMOF explored. Therefore, we developed toxicological studies about coated NMOF by silica. Our results was confirmed by FT-IR, XRD, SEM, and MTT. Observation of releasing of drugs showed that coated NMOF is much better than NMOF alone, due to its slow releasing.