A Systematic Study of ZnO/CuO Core/Shell Nanostructures by Microwave Method and Investigation its Antibactrial Effect

Abstract: Recently nanoparticles delivery system has been proposed as colloidal drug carriers. Nanoparticles (NP) are a type of colloidal drug delivery system comprising particles with a size range from 10 to 1000 nm in diameter [1]. Today, to reduce complications and increase the efficiency of chemotherapy agents nanotechnology and nanomateriales are being used in the medical field [2]. PEG is a non-biodegradable polymer and PEGylation can impart several significant pharmacological advantages over the unmodified form, such as improved drug solubility, reduced dosage frequency, without diminished efficacy with potentially reduced toxicity, extended circulating life, increased drug stability, and enhanced protection from proteolytic degradation; peglyated forms may also be eligible for patent protection[3]. In this work we synthesized ZnO/CuO nanostructures pegylated by simple and fast microwave method assistant reverse micelles, Reverse micelles protocol creates many advantage in stability, particle size control, morphology, density, loading level, distribution, uniformity, charge and purification. Based on the statistical results ZnO/CuO nanostructures placed in the hydrophilic substrate. The effect of microwave and concentration of surfactant on the surface area, pore diameter and pore volume of the final product was systematically studied using Taguchi technique. ZnO/CuO core/shell pegylated nanostructures, indicating a ZnO as core and CuO as shell and continuous micelles chains around this structures. Products were characterized by UV−Vis spectra, X-ray diffraction, scanning electron microscopy (SEM), Dynamic light scattering (DLS), transmission electron microscopy (TEM) and nitrogen adsorption [i.e. Brunauer–Emmett–Teller (BET) Surface Area Analysis]. Taguchi technique, Results of SEM images show ZnO/CuO core/shell pegylated nanostructures synthesized by emulsion method are smaller than ZnO/CuO core/shell pegylated synthesized by microwave method, this event prove plays micelles as nanoreactors. Summary of the formation ZnO/CuO Core/Shell pegylated suspension is shown in Scheme 1.