شماره ركورد كنفرانس :
4818
عنوان مقاله :
Association of rs2665390 and rs2854344 as a risk factor for ovarian cancer
عنوان به زبان ديگر :
Association of rs2665390 and rs2854344 as a risk factor for ovarian cancer
پديدآورندگان :
vahidi Maryam marri.vahidi@gmail.com Department of Medical Genetics National Institute of Genetic Engineering and Biotechnology_ Tehran_ Iran , Heidari Farid heidari@nigeb.ac.ir Department of Medical Genetics National Institute of Genetic Engineering and Biotechnology_ Tehran_ Iran , Houshmand Massoud massoudh@nigeb.ac.ir Department of Medical Genetics National Institute of Genetic Engineering and Biotechnology_ Tehran_ Iran
كليدواژه :
ovarian cancer , polymorphism , a risk factor
عنوان كنفرانس :
سومين همايش بين المللي و يازدهمين همايش ملي بيوتكنولوژي جمهوري اسلامي ايران
چكيده فارسي :
Ovarian cancer is one of the most common cancers of women in the world and the ninth most common in Iran. Usually, ovarian cancer detected when the patient is in advance stage so the prediction tools are valuable. The aim of this study was diagnosed biomarker in ovarian cancer in the Iranian population. In other countries have been shown rs2665390 (located on the TIPARP gene) and rs2854344 (located on the Rb1 gene) are associated with ovarian cancer as a risk factor. In this study, our main goals find out whatever these two polymorphism is associated with ovarian cancer risk. We collected peripheral blood samples from 50 normal women and after extraction DNA, the genes were studied with Tetra-ARMS PCR technique. The results show that for two polymorphisms rs2854344 and rs2665390 most of the samples were heterozygote. Regarding the normal samples were heterozygote, we expect these two polymorphisms do not play an important role in ovarian cancer. These results led us to find suitable biomarkers for the population and help physicians for prediction.
