Nanocomposite Decorated Glassy Carbon Electrode for Simultaneous Determination of Dopamine and Uric acid

Abstract: In this study, a sensitive sensor was constructed based on multi-wall carbon nanotubes and TTF-TCNQ as a conductive organic complex. The complex was fixed on the modified MWCNT/GCE with the droplet method. The modified TTF-TCNQ/MWCNT/GC was used as a sensing probe in a voltammetric system for the determination of dopamine and uric acid. The physical characterization of TTF-TCNQ/MWCNT/GCE was performed with field emission scanning electron microscopy. At the optimum conditions, the modified electrode shows the good electrocatalytic activity for oxidation of dopamine and uric acid in low applied potential in 0.1M PBS solution pH 7. The linear dynamic range for dopamine and uric acid were obtained 5.0×10-8 – 3.5×10-5M and 5.0×10-7 – 2.1×10-4 M, respectively. As well as, the limits of detection were calculated 3.4×10-8 M and 4.2×10-7M, respectively. Due to the excellent electrocatalytic performance of the present sensor, the electrode was successfully applied for determination and monitoring the level of dopamine and uric acid in human physiological fluids.