Biochemical Studies of A New Schiff Base Ligand and Its Complex Containing 2-Thiophenecarboxaldehyde

A new Schiff base ligand containing 2-thiophenecarboxaldehyde and its zirconium complex was synthesized and their structure details were investigated by different spectroscopies. DNA interaction of the compounds has been investigated by the fluorescence and UV-Vis spectroscopies and intrinsic binding constants were calculated. In order to quantitatively compare the binding strength of bonds between compounds and DNA, the intrinsic binding constants (Kb and Kf) were calculated. The results suggest that interactions between the compounds and CT-DNA occur by intercalative binding modes. The positive values of enthalpy and entropy showed hydrophobic interaction.