شماره ركورد كنفرانس :
4865
عنوان مقاله :
Self-assembly and DNA Binding of Cationic Gemini Amphiphiles: A Biophysical Study
پديدآورندگان :
Davoodia S samin.davoodi72@gmail.com Alzahra university, Tehran , . Pourhosseinia P. S p.pourhosseini@alzahra.ac.ir Alzahra university, Tehran , Ghorbanmehra N nassim.ghorbanmehr@gmail.com Alzahra university, Tehran , Sabouryb A.A saboury@ut.ac.ir bInstitute of Biochemistry and Biophysics, Tehran , Najafic F fnajafi@icrc.ac.ir In this research, the interaction of cationic gemini surfactants, having a 6 methylene group (C6) as a spacer and urethane bonds in their chains, with plasmid DNA (pDNA) is investigated by conductometry. Results confirm the formation of surfactant-DNA complex. The thermodynamic parameters of binding, such as changes in the standard Gibbs free energy of micellization (ΔGºmic) and that of complex formation (ΔGºagg) are reported. Besides, the critical aggregation concentration (cac), the polymer saturation point (psp), the ionization degree of complexes (α1) and that of micelles (α), are determined. ؛ , Landarania Z landzah@yahoo.com Alzahra university, Tehran
كليدواژه :
(conductivity , critical micelle concentration , degree of ionization , gemini surfactant , polymer saturation point (psp
عنوان كنفرانس :
بيست و دومين كنفرانس ملي شيمي فيزيك ايران
چكيده فارسي :
In this research, the interaction of cationic gemini surfactants, having a 6 methylene group (C6) as a spacer and urethane bonds in their chains, with plasmid DNA (pDNA) is investigated by conductometry. Results confirm the formation of surfactant-DNA complex. The thermodynamic parameters of binding, such as changes in the standard Gibbs free energy of micellization (ΔGºmic) and that of complex formation (ΔGºagg) are reported. Besides, the critical aggregation concentration (cac), the polymer saturation point (psp), the ionization degree of complexes (α1) and that of micelles (α), are determined.
