The Aqueous Solubility of Indomethacin in the Presence of Tetrabutylammonium Bromide Based Deep Eutectic Solvents at Various Temperatures

Deep eutectic solvents (DESs) have recently been getting a great deal of attention in many fields of science and technology. The objective of this study was to peruse the solubility of indomethacin (IMC) as sparingly soluble drug in some tetrabutylammonium bromide (TBAB) based DESs (TBAB/ethylene glycol and TBAB/glycerol). The shake flask method has been employed in this study at temperature range T = (298.15-313.15) K and atmospheric pressure (P = 86.6 kPa). The results showed that the solubility of IMC was obtained approximately 17000-fold more than its solubility in water. The solubility data were accurately correlated by the famous local composition activity coefficient models including e-NRTL and UNIQUAC.