ZnO Nanoparticles Anchored 3-D Ni-Foam Electrode for Electrochemiluminescence Determination of Amoxicillin

In this work, an electrochemiluminescence (ECL) sensing platform for sensitive determination of amoxicillin has been introduced. The ECL detection procedure was performed on the ZnO nanoparticles modified Ni-foam electrode in the presence of luminol. The size of ZnO nanoparticles was controlled by the silica templates on the electrode surface. The morphological studies were carried out using field emission scanning electron microscopy (FESEM) and electrochemical impedance spectroscopy (EIS). The obtained linear dynamic range of the method was from 4.0×10-11 to 6.5×10-5 M with a detection limit of 8.3 × 10-12 M (S/N = 3). The proposed modified electrode showed excellent ECL responses with high sensitivity, selectivity and stability for the determination of amoxicillin at the optimal conditions, which makes it a suitable sensor for submicromolar detection of amoxicillin in solutions. The analytical performance of this sensor has been evaluated for the detection of amoxicillin in milk samples with satisfactory results.