چكيده فارسي :
The development of rapid, sensitive, efficient and automated analytical methods for the determination of drug residues and contaminants in food samples has been attracted more consideration due to food direct effect on human health. In spite of important developments in analytical devices, direct analysis of the compounds in the original matrix is a challenging issue and in many cases preliminary steps for isolation and enrichment of the analytes previous to analysis is vital. Thus many sample preparation methods have been developed. The main objective of sample preparation methods is to purify the sample, increase the concentration of the analytes, and possibly modify the sample to adapt it to the requirements of the test equipment. Three main types of sample preparation methods were developed including single drop microextraction, hollow fiber liquid phase microextraction, and dispersive liquid-liquid microextraction. In all cases the design of methods that minimize or even exclude the use of hazardous substances is a challenging parameter. Hence the need to develop extraction methods that meet the requirements of green chemistry has attracted more attentions. For this purpose, the use of ionic liquids (ILs), deep eutectic solvents (DESs), and lighter than water organic solvents were used in extraction steps.
