Sensitive determination of Gefitinib in human biological samples by differential pulse voltammetry based on carbon paste electrode modified by MMWCNTs/PAN NFs

In the present work, the electrochemical oxidation of new generation of anti-cancer drug, Gefitinib ,using by differential pulse voltammetry based on carbon paste electrode modified by MMCNTs/PAN NFs (MMWCNTs/PAN NFs/CPE) has been reported. The result of a study showed that Gefitinib provided well-shaped oxidation peak at positive potential of +1.09 V (vs. EAg/AgCl) in the phosphate buffer solution at pH 2.5. The experimental conditions, i.e. pH, modulation amplitude, a modulation time, a step potential, and a scan rate, were optimized, A simple, rapid, selective and sensitive DPV procedure for the determination of Gefitinib was performed in the concentration range of 2.24 ×10-9 – 5.59 × 10-5 mol L-1 with the limit of detection (LOD) and the limit of quantification (LOQ) of 2.9×10-10 and 9.6×10-10, respectively. The proposed method with using anodic signal of Gefitinib at MMWCNTs/PAN NFs/CPE shown comparable detection limit as for HPLC method and fluorescent indicator in the determination of this anticancer drug.