Sensitive determination of omeprazole in human biological sample by differential pulse voltammetry based on carbon paste electrode modified by MMWCNTs/PAN NFs

In the present work, the electrochemical oxidation of new generation of omeprazole drug, using by differential pulse voltammetry based on carbon paste electrode modified by MMCNTs/PAN NFs (MMWCNTs/PAN NFs/CPE) has been reported. The result of a study showed that omeprazole provided well-shaped oxidation peak at positive potential of +0.89 V (vs. EAg/AgCl) in the phosphate buffer solution at pH 3.0. The experimental conditions, i.e. pH, modulation amplitude, a modulation time, a step potential, and a scan rate, were optimized, A simple, rapid, selective and sensitive DPV procedure for the determination of omeprazole was performed in the concentration range of 2.89 ×10-9 – 7.2 × 10-5 mol L-1 with the limit of detection (LOD) and the limit of quantification (LOQ) of 3.9×10-10 and 1.3×10-9, respectively. The proposed method with using anodic signal of omeprazole at MMWCNTs/PAN NFs/CPE shown comparable detection limit as for nikel-zinc ferrite graphene glassy carbon electrode and MWCNTs/Gtaphene oxide/Pyrogallol camposite carbon paste electrode in the determination of this omeprazole drug.