شماره ركورد كنفرانس :
3550
عنوان مقاله :
Synthesis of PS-PAA based polymersome and investigation of its capability for loading and releasing of electroactive Methylene Blue (MB) indicator
پديدآورندگان :
Aghaziyarati Farahani Fatemeh Electroanalytical chemistry laboratory, Department of Analytical chemistry, faculty of chemistry, university of Tabriz, Iran , Alipour Esmaeel esmaeel313@gmail.com Electroanalytical chemistry laboratory, Department of Analytical chemistry, faculty of chemistry, university of Tabriz, Iran; , Amini-Fazl Mohammad Sadegh ms.amini@tabrizu.ac.ir Department of Applied chemistry laboratory, , faculty of chemistry, university of Tabriz, Tabriz, Iran; , Mohammadi Reza r.mohammadi@tabrizu.ac.ir Polymer Research laboratory, Department of Organic and Biochemistry, faculty of chemistry, university of Tabriz, Tabriz, Iran;
كليدواژه :
Polymersome , vesicles , copolymer , loading , , release , ATRP , RAFT , methylene blue , tetrahydrofuran
عنوان كنفرانس :
بيست و پنجمين سمينار ملي شيمي تجزيه انجمن شيمي ايران
چكيده فارسي :
Polymersomes are a type of synthetic vesicles composed of amphiphilic block copolymers (a molecule that has both a hydrophilic region and a hydrophobic region), which is used due to the characteristics of the adjustable membrane and the ability to encapsulate a wide range of drugs and molecules due to their colloidal stability [1]. Polymersomes can be synthesized in different sizes (from 50 nm to 10 μm), which these sizes vary depending on the chemical composition, length of the polymer groups, the preparation method and the reaction conditions [2].Polymersomes with different species of copolymers have also been designed and produced as pharmaceuticals, which have the physicochemical stability, the loading mechanism and simultaneous release of hydrophobic and hydrophilic drugs and adjustable permeability. Polymersomes with respect to their synthesis conditions can exhibit different behaviors relative to external stimuli, such as temperature, pH, chemical stimulus, which various behaviors can be made in form of deformation, change of surface properties, dissolution, etc. There are various methods to synthesize polymersomes, such as atom transfer radical polymerization (ATRP) and radical polymerization controlled by reversible addition-fragmentation chain transfer (RAFT) process [3].
