Synthesis,Characterization and antimicrobial studies of chitosan / poly (vinyl alcohol ) /nano Zno composite nanofibers

Nanofibers of (chitosan / poly (vinyl alcohol)/nano ZnO) were prepared by electrospinning method. ZnO nano particles of size (~20 nm) was synthesized and characterized by uv spectroscopy, XRD and infrared spectroscopy (IR).nanofibers were prepared in the varying ratio of chitosan, PVA and nano ZnO.The prepared composite nanofibers were characterized using FT-IR, XRD and SEM studies.The antimicrobial activities of CS/PVA/nano ZnO mats were examined with different bacteria against the measurement of clear zone diameter and found that CS/PVA/nano ZnO mats shows antibacterial activity due to presence of nano ZnO.our researchs suggest that such nano fibers could be used to biomedical applications. Electrospinning is a simple and a low cost method for formation of nanofibers.nanofibers have interesting specifications such as high pores with very small pore size and very large surface area-to-volume ratio.Therefore, nanofiber can be hope-giving and assured materials for many biomedical applications such as wound dressing, drug delivery, tissue templates,etc. Chitosan, a (1-4)-linked 2-amino-2-deoxy-D-glucopyranose is obtained from chitin.It is one of the most plentiful natural polysacharides,due to several unique properties: biodegradability, biocompatibility and antimicrobial properties.It is nontoxic for the human body.chitosan is insoluble in water,and common organic solvents,but it easily dissolves in aqueous inorganic and organic acid media. Since, electrospinning of chitosan itself is difficult, chitosan has been mixed with other synthetic on natural polymers such as PVA and poly (ethylene oxide).PVA is non-toxic, biodegredable and water- soluble synthetic polymer and has been used on vast scale in biomaterial application. During the last few years, Synthesis of nanostructured oxide materials have been acquire significant attention. nano crystalline Zno is an interesting and promising material for constitutional research and industrial application. Its incomparable optical and electrical properties are useful for gas sensor, solar cells, nano lazers, etc. The surface morphology, crystalline structure, were investigated by scanning electron microscope, X-ray diffractometer (XRD).In this work, we have blended chitosan with PVA for preparing them in to nanofibers and we developed CS/PVA/Nano Zno nanofiber mats for biomedical applications.[1-3].