Cobalt Metal Organic Framework as Sorbent for Fast Determination of ‎Bisphenol A in Juice and Drinking Water Samples by Pipette tip Solid Phase ‎Extraction

Cobalt metal organic frame work (Co-MOF) was prepared and used for solid phase extraction of ‎Bisphenol A (BPA). Synthesize of Co-mof was performed with rapid ultrasound assisted method by ‎using of cobalt nitrate and pyridine 2, 6-dicarboxilic acid dissolved in ethanol. Micro solid phase ‎extraction (Micro- spe) applied in pipette- tip as micro column for extraction and determination of ‎BPA. All parameters that influenced extraction efficiency such as pH, sample volume, amount of Co-‎mof, type and volume of eluent, number of draw/ eject cycles for sample and eluent and effect of ‎temperature were tested and optimized. Results showed that best extraction efficiency obtained at ‎pH 3, 150 µl of sample volume, 3 mg of adsorbent and 10 µl of methanol. Numbers of draw/ eject ‎cycles for both sample and eluent were 7 cycles. Limit of detection (LOD) and limit of quantification ‎‎(LOQ) of this method were 0.07 and 0.3 µg l-1 while linear dynamic range (LDR) was 0.3to 300 µg l-1. This ‎method applied successfully for determination of BPA in 7 canned food and drinking water samples.‎