Applying chemometric methods studying multidimensional data is transforming them into multiparty data and analyzing them with MCR-ALS in order to measurement of Rizatriptan drug in actual samples based upon studying its degradation

Spectrophotometric-kinetic technique is a strong method for the investigation of drug destruction in the presence of oxidants [1].In a spectrophotometric-kinetic measurement, it is common to order the obtained matrices along time dimension.One method for studying multidimensional data is transforming them into multiparty data and analyzing them with MCR-ALS (Multivariate Curve Resolution- Alternating Least Square ( method. To do so, multidimensional data-construction matrices are aligned in the direction of one dimension of the matrices. By using rate differences in the destruction of Rizatriptan in the presence of interfering drug and spectrophotometric-kinetic data obtained during the destruction process of oxidants such as chlorine and studying the creation and selection of optimum conditions in terms of drug concentration and oxidant and pH of the reaction medium, simultaneous measurement and recording of 2D spectrophotometric-kinetic data can be performed providing second order algorithms for data analysis.In this work, Using MCR-ALS chemometric method and applying non-negativity and unimodality constrains in both concentration and spectrum dimensions and by comparing results obtained by applying more constrains such as equality constrains in concentration and/or spectrum dimensions as well as applying trilinearity constrains, the responses were improved [2-3] . destruction of Rizatriptan drug under optimum conditions gave linear rang of (5*10-7- 2*10-5) and using MCR-ALS technique, simultaneous drug measurements are possible without the need for knowing interfering species.