شماره ركورد كنفرانس :
3550
عنوان مقاله :
Organic electro-synthesis as a new facile and green method for One-pot synthesis of nano size particles of dihydro pyridines derivatives via a multi component reaction
پديدآورندگان :
Askari Omolbanin Department of chemistry, Karaj branch, Islamic Azad University, Karaj, Iran , Makarem Somayeh s.makarem@kiau.ac.ir Department of chemistry, Karaj branch, Islamic Azad University, Karaj, Iran, s_makarem@sub.ac.ir / , Kurdtabar Mehran Department of chemistry, Karaj branch, Islamic Azad University, Karaj, Iran
كليدواژه :
Nanoparticles , electrochemical , imidazoline , electrosynthesis
عنوان كنفرانس :
بيست و پنجمين سمينار ملي شيمي تجزيه انجمن شيمي ايران
چكيده فارسي :
An electrochemical strategy is presented in order to synthesize nanoparticles of dihydro pyridines, by an electro-generated base from propanol anion in a one-pot, three-component reaction. This reaction includes the condensation of isatin derivatives, 1,3 indandione and 2-Nitromethylene-imidazolidine in an undivided cell in the presence of sodium bromide as an electrolyte at 50◦C. The protocol has the advantages of easy work-up, high yields, wide application scope, and an environmentally benign procedure compared with the reported methods [1-2]. In addition, size reduction of products by this method helps to improve solubility and bioavailability, reduce toxicity, enhance release, and provide better formulation opportunities for drugs [3-4].
