Spectroscopy study of synthesize and stability of inclusion complexes of 2-(2,3-dimethylphenyl)aminobenzoic acid with beta cyclodextrin in aqueous solution

2-(2,3-dimethylphenyl)aminobenzoic acid belongs to a family of nonsteroidal anti-inflammatory drugs (NSAIDs) [1]. The main objective of this study was to synthesize the host-guest inclusion complexes of 2-(2,3-dimethylphenyl) aminobenzoic acid with beta-cyclodextrin and study of stability and solubility of drug/βCD by UV-Vis FT-IR and 1HNMR spectroscopy. The UV absorption maximum of drug appears at 335nm. Cyclodextrins (CDs) are cyclic oligosaccharides of α-(1,4) linked D-glucose units in a ring formation containing a relative hydrophobic central cavity and hydrophilic outer surface. The synthesis involved a series of protection and deprotection reaction. The experimental results revealed that the inclusion process is a spontaneous process [1]. The enhancement of drug solubility in the presence of β-CD was detected. The stability constants were calculated by data to Benesi–Hildebrand equation [3]. Solubility studies demonstrated the formation of the drug/βCD inclusion complex with 1:1 stoichiometry. antiactivity of 2,2-diphenyl-1-picrylhydrazyl (DPPH.) with drug and cyclodextrins complexes were done. The experimental results that the inclusion complexes of drug-βCD was the most reactive than its free form into antioxidant activity [2]. All these techniques revealed that 2-(2,3-dimethylphenyl)aminobenzoic acid form inclusion complexes with β -CD in aqueous solution.