Magnetic nanoparticles based Sensors and biosensors

Magnetic nanoparticles (MNPs) are widely used in the development and fabrication of sensors and biosensors. MNPs be dispersed in the sample and collected the targets then be integrated into the transducer materials by their attraction by an external magnetic field onto the active detection surface of the (bio) sensor. This work describes and discusses our recent applications of MNPs in sensors and biosensors. Core-shell Fe3O4@SiO2 is one of the most used in biosensors, since it contributes to stabilization of MNPs in solution and enhances the binding of ligands at the surface of MNPs. Core-shell Fe3O4@SiO2 is also much used in modifying surfaces of MNPs. The Core-shell Fe3O4@SiO2 modified whit various molecules and biomolecules such Antibodies, DNAzymes and aptamers. Electrochemical based magneto-immunoassay for simultaneous determination of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP), electrogenerated chemiluminescence(ECL) for determination of Hepatitis B virus surface antigen and fluorescence based sensors and biosensors are some of the work has been reported.