The Role of nanoparticles in Drug Analysis

Complexity of the biological matrixes e.g. plasma and urine and low doses of the drugs, leads to the growing trends of sample treatment and preconcentration processes in drug analysis which consequently leads to the development of various novel analytical methods. Liquid-liquid extraction (LLE) and solid phase extraction (SPE) are two common sample treatment methods with the limitation of high volumes of toxic organic solvents consumption, being time consuming and frangibility of the cartridges. Magnetic solid phase extraction (MSPE) is a novel sample treatment method with the advantages of magnetic properties that leads to easy separation of the adsorbent from the sample medium in the presence of external magnetic field without any filtration or centrifugation. Moreover, application of nano structure magnetic adsorbents provides high surface-area-to volume that makes maximum extraction efficiency of the analytes from the medium in comparison with other adsorbents. Polymeric magnetic nano adsorbents (PMNAs) are a combination of magnetic cores and polymeric shells. This polymeric shells offer a functional surface for MNPs providing a selective performance for MNPs in drug analysis. The presentation tries to share the experiences of presenter along with new related approaches in the application of MNPs and PMNPs in drug analysis.