شماره ركورد كنفرانس :
5048
عنوان مقاله :
A Mathematical Pattern Development and Optimization for Experimental Conditions in RESS Process
Author/Authors :
Fatemeh ،Zabihi Department of Chemical Engineering - Ayatollah Amoli Branch - Tehran, Iran , Mohammad Mehdi ،Akbarnejad , Ali ،Vaziri Department of Chemical Engineering - Science & Research Branch - Tehran, Iran , Maryam ،Otadi Department of Chemical Engineering - Central Branch - Tehran, Iran , Ahmad Reza ،Bozorgmanesh Department of Chemical Engineering - Science & Research Branch - Tehran, Iran
كليدواژه :
Mean Particles Size , RESS , Sp-line equation , Pre-expansion Pressure , Nozzle Temperature
عنوان كنفرانس :
ششمين كنگره بين المللي مهندسي شيمي
چكيده لاتين :
The experimental work was aimed at gaining a fundamental observation of the expansion nozzle temperature (80-
100˚C) and the dissolution pressure effects (75-120 bar) on the mean particles diameter in RESS processing of
ibuprofen-CO2 system. A 2-dimentional Sp-line equation has been fitted on the experimental results. The mean
particles size values were calculated in all experimental points by the fitted equation and results were compared with the
experimental data to confirm the model accuracy (8%). The optimum operational point (dissolution pressure of 86 bar
and nozzle temperature of 82˚C ), that leads to the minimum mean particles diameter (40 nm), were also determined by
mathematical optimization method and was confirmed experimentally. Meanwhile the mean particle diameters were
predicted in 600 more operational points by the fitted equation and results were drawn in form of a that show the nozzle
temperature and dissolution pressure simultaneous impacts on the products mean size.
