Latest fertility preservation techniques in young women with breast cancer: a systematic review

Today breast cancer (BC) is the most common malignancy reported in women society. Due to the statistics 1.5 million women worldwide below the age of 45 years are affected by BC each year. Multimodal treatments including chemotherapy are received by diagnosed cases but post-treatment side effects of gonad toxicity and anticancer treatments lead the patient to infertility by primordial follicles damage. In briefly these can lead to early menopause or premature ovarian insufficiency. Beside the importance and admire of young women to have children after treatment process, failure to fulfil this desire has been associated with worse mental health. Currently available preservation methods for these patients fall into two major categories: 1. cryopreservation: oocytes cryopreservation, embryos cryopreservation and ovary tissue cryopreservation (most recommended for prepubertal girls); 2. Gonadotropin realizing hormone (GNRH) agonists. In this case, this review aims to analyze the mentioned suitable treatments for fertility preservation, their methods, efficiency and effectiveness.