Design Electrochemical sensor based on MnCo2O4.5/B, N co-doped reduced graphene oxide nanocomposite for detection of paracetamol

Paracetamol (acetaminophen, N-acetyl-aminophenol) is widely used as an antipyretic and analgesic drug.Generally, paracetamol does not show any harmful side effects if used in limited amounts. However, excessive consumption of this compound and its chronic use causes toxic metabolites and damages the kidneys and liver. According to these cases, a simple, sensitive, fast, and accurate analytical method is needed to measure paracetamol in human plasma and pharmaceutical products [1-3].This work reports a sensitive electrochemical sensor based on manganese cobaltite Hybridization Boron and Nitrogen co-doped reduced graphene oxide nanocomposite (MnCo2O4.5/B, NrGO) modified carbon paste electrode (CPE) for the determination of Paracetamol (PA). The MnCo2O4.5/rGO nanocomposite was prepared by simple hydrothermal method and sonication. The morphology and structure of the composite prepared with FE-SEM, EDX, Mapping, FTIR, XPS, XRD, and Raman techniques were investigated. Compared with the CPE electrode, the modified MnCo2O4.5/B, N-RGO/CPE electrode showed better electrocatalytic activity for the oxidation of paracetamol. Measurements were investigated using cyclic voltammetry and differential pulse voltammetry. Using the impedance technique, the level of surface conductivity was checked. The results showed an increase in surface conductivity. The detection limit was 0.19 μM and the range of linear response was 5.0-1333.0 μM. The developed sensor had good features such as high sensitivity, high reproducibility and repeatability, low detection limit, and fast response time. The results obtained from the real sample of paracetamol tablets and human blood serum were completely satisfactory.