Highly efficient pH-responsive Ag @ Chitosan core shell nano particles for Drug Delivery and anti-human breast cancer properties

This study reports developing novel smart drug delivery systems (DDS) that have great importance in anticancer therapeutics. we report the preparation and stabilization of silver nanoparticle as core, and chitosan dihydroxyphenyl acetamide as a shell. The Nano Core- shell was used as a nano carrier for doxorubicin (DOX) as anti-cancer drugs against MCF-7 human breast cancer cells. The nano core shell was designed to be sensitive to pH and it demonstrated a controlled drug release that can be able to distinguish between normal and cancer tissues. At pH 7.8, the minimum content of drug release was observed for sample fabricated with variable contents of chitosan. At pH 4.3, the effect of chitosan content revealed that the rate of DOX release tends to decrease as its content increased. During two days, 97 % of the loaded DOX released from carriers containing high and low contents of chitosan, respectively. Besides, this Ag@Chitosan nano- core shell carrier shown pH-sensitive drug release. The morphology of the synthesized silver core-chitosan shell nanoparticles was observed by transmission electron microscopy (TEM) and X-ray diffraction (XRD) techniques, and showed a well-defined core-shell structure. [1,2].