شماره ركورد كنفرانس :
5328
عنوان مقاله :
Anticancer drug imatinib/β-cyclodextrin inclusion complex to enhance solubility and bioavailability: Molecular modeling studies
پديدآورندگان :
karpour Matin a Department of Chemistry, Faculty of Science, University of Guilan, Rasht 41335‑1914, Iran , Alizadeh Nina Department of Chemistry, Faculty of Science, University of Guilan, Rasht 41335‑1914, Iran.
كليدواژه :
Inclusion complex , β Cyclodextrin , Stability constant , Imatinib , Molecular modeling
عنوان كنفرانس :
بيست و سومين كنفرانس شيمي فيزيك انجمن شيمي ايران
چكيده فارسي :
Imatinib anticancer drug (IMA) under the brand name Gleevec Glivec with the ability to treat diverse cancers as a guest drug and beta-cyclodextrin (β-CD) as a host molecule were used. The objective of this study was to investigate the inclusion complex interaction of imatinib (IMA) with beta-cyclodextrin (β-CD) cavity to improve the solubility, bioavailability and stability of this drug.
