شماره ركورد كنفرانس :
5328
عنوان مقاله :
Molecular features of interaction between VEGFR-2 and Linifanib and Semaxanib using a combination of computational methods
پديدآورندگان :
Karami Leila l_karami@khu.ac.ir Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
كليدواژه :
VEGFR , 2 , molecular docking , Molecular dynamics simulations , Linifanib , Semaxanib.
عنوان كنفرانس :
بيست و سومين كنفرانس شيمي فيزيك انجمن شيمي ايران
چكيده فارسي :
Due to the importance of Vascular Endothelial Growth Factor Receptor type 2 (VEGFR-2) in angiogenesis of cancerous tumors, in this work, the molecular mechanism of interaction between the VEGFR-2 and linifanib and semaxanib as inhibitor was investigated using the molecular docking, molecular dynamics (MD) simulation. For this purpose, post MD analysis (structural and thermodynamics) were .performed
