پديدآورندگان :
Namdar Ashkan ashkan.namdar@email.kntu.ac.ir Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran , Borhanzadeh Tina tinaborhan21@gmail.com Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran , Salahinejad Erfan erfan.salahinejad@gmail.com Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran
كليدواژه :
Local drug delivery , Burst and sustained release kinetics , Historical data , Pharmaceuticals
چكيده فارسي :
Osteomyelitis is a bone infectious disease that is mainly caused by Staphylococcus Aureus bacteria. Poly lactic-co-glycolic acid (PLGA)-vancomycin drug-carrier pair is a well-established drug delivery agent to act against this bacterium. This study implemented a combined method of meta-analysis and design-of-experiments (DoE) to optimize the PLGA molecular weight of PLGA-VAN systems for Staphylococcus aureus-caused biofilm prevention and eradication. The criteria of success were assigned to be the drug concentrations of 2-8 μg/ml in the burst phase of release. It was concluded that higher molecular weights are needed for effective treatment by increasing the lactide-to-glycolide (LA/GA) ratio.
