شماره ركورد كنفرانس
5339
عنوان مقاله
Meta-analytical optimization of PLGA molecular weight in PLGA-vancomycin capsules for Staphylococcus aureus-caused biofilm prevention and eradication
پديدآورندگان
Namdar Ashkan ashkan.namdar@email.kntu.ac.ir Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran , Borhanzadeh Tina tinaborhan21@gmail.com Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran , Salahinejad Erfan erfan.salahinejad@gmail.com Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran
تعداد صفحه
4
كليدواژه
Local drug delivery , Burst and sustained release kinetics , Historical data , Pharmaceuticals
سال انتشار
1402
عنوان كنفرانس
دوازدهمين كنفرانس بين المللي مهندسي مواد و متالورژي
زبان مدرك
انگليسي
چكيده فارسي
Osteomyelitis is a bone infectious disease that is mainly caused by Staphylococcus Aureus bacteria. Poly lactic-co-glycolic acid (PLGA)-vancomycin drug-carrier pair is a well-established drug delivery agent to act against this bacterium. This study implemented a combined method of meta-analysis and design-of-experiments (DoE) to optimize the PLGA molecular weight of PLGA-VAN systems for Staphylococcus aureus-caused biofilm prevention and eradication. The criteria of success were assigned to be the drug concentrations of 2-8 μg/ml in the burst phase of release. It was concluded that higher molecular weights are needed for effective treatment by increasing the lactide-to-glycolide (LA/GA) ratio.
كشور
ايران
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