پديدآورندگان :
Mohammadi Elaheh Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Behnam Behzad Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran , Safdarian Mehdi Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , Mahdavinia Masoud Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. mahdavimasoud@yahoo.com
كليدواژه :
Keywords: behavioral , brain , carbon dots , mice
چكيده فارسي :
Background: Carbon dots (CDs) are a relatively new type of ultrasmall nanoparticles that have been used as effective theragnostic platforms due to their high biocompatibility. Increased drug solubility and targeting, as well as drug transport through impermeable membranes (i.e., the blood-brain barrier), are all possible with the help of these particles. Herein, CDs were synthesized with the strategy of using Cuminum cyminum as a natural source for crossing the blood-brain barrier. Methods: The CDs were synthesized using Cuminum cyminum. Fifteen mice were injected via the tail vein with a single injection per week of either 10 or 50 mg/kg for 14 days. The control group received normal saline. Behavioral performance and inflammatory mediators were evaluated in addition to the histopathological examination. Results and discussion: CDs made using these precursors show excitation wavelength-dependent emission. No behavioral changes were observed. Moreover, the inflammatory mediators expression was slightly upregulated at a dose of 50 mg/kg. The histopathological examination also corroborated these findings. Conclusion: These CDs had slight behavioral and neurotoxic effects at high doses that show this function opens up potential avenues for drug delivery and brain imaging.
