شماره ركورد كنفرانس :
5310
عنوان مقاله :
Niosome containing miRNA-15a, combination of gene therapy and nanotechnology for treating prostate cancer
پديدآورندگان :
Akhlaghi Milad Department of clinical biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Afshoun Alireza Medical Nanotechnology Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi Uviverstity of Medical Sciences, Yazd, Iran , Zhian Mehrizi Mahtab Medical Nanotechnology Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi Uviverstity of Medical Sciences, Yazd, Iran , Haghirosadat Bibi fatemeh Medical Nanotechnology Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi Uviverstity of Medical Sciences, Yazd, Iran. fhaghirosadat@gmail.com
كليدواژه :
Keywords: Prostate cancer , niosome , target therapy , gene therapy , nanotechnology
عنوان كنفرانس :
چهارمين كنفرانس بين المللي نانو پزشكي و نانو ايمني
چكيده فارسي :
Aim and Background: The combination of drug delivery and gene therapy could be considered a new approach for treating one of the most common types of cancer among men, prostate cancer. This study is aimed to synthesis and characterize niosomes containing miRNA-15a for improving prostate cancer treatment. Methods: Firstly miRNA-15a was synthesized on cationic niosomal system, then Du-145, PC3 cancer cells, and HFF normal cells were treated with none-loaded niosomes, free miRNA-15a and miRNa15-niposome and cell viability was calculated by MTT assay. Results and discussion: Along with appropriate features of niosomes, MTT results showed that the viability percentage of Du-145 and PC3 cells treated with non-loaded niosomes, free-miRNA-15a, and miRNA-15a niosome were 100%-99%, 97%-98%, and 90%-88% respectively. Conclusion: Niosome containing miRNA-15a opens a new safe window for the treatment of prostate cancer.
