پديدآورندگان :
Mazaheri Mohadeseh Nanochemical Engineering Department, Faculty of Advanced Technologies, Shiraz University, Shiraz, Iran , Tohidi Maryam Nanochemical Engineering Department, Faculty of Advanced Technologies, Shiraz University, Shiraz, Iran. matohidi@Shirazu.ac.ir , Rastegari Banafshe Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Science, Shiraz, Iran , Keshavarzi Zahra Nanochemical Engineering Department, Faculty of Advanced Technologies, Shiraz University, Shiraz, Iran , Jamali Fatemeh Nanochemical Engineering Department, Faculty of Advanced Technologies, Shiraz University, Shiraz, Iran.
كليدواژه :
Metal , organic framework (MOF) , biomineralization , targeted drug delivery , polysaccharide
چكيده فارسي :
Aim and Background: Bio-metal–organic frameworks (BioMOFs) are a new class of nanoporous materials that represent a subclass of MOFs. BioMOFs consist of two main part, metal ions and ligand. BioMOF are excellent supporting matrices due to the low toxicity of metals, high encapsulation efficiency, and moderate synthetic conditions. One of the potential applications of BioMOF is in drug delivery. Methods: Herein, desired BioMOFs was synthesized by dicarboxylic acid as ligand and Cu2+ as metal node in the presence of polysaccharide (PS) and drug (Curcumin) by changing parameters such as temperature, concentration, pH and solvent conditions. product was dried after purification via continuous centrifugation with water. Results and discussion: We used some characterization techniques such as SEM to show The morphology and size of the product. Release test to show the rate of drug release from the MOF structure and FTIR and XRD to prove the presence of materials and functional groups in the MOF structure. Conclusion: In this study, BioMOF was synthesized by biomineralization method for encapsulation of curcumin. Polysaccharides were used to enhance the biocompatibility.
