Molecular docking and in-vitro tyrosinase inhibitory potential of gallic acid and its nanoniosome

Aim and Background: Nano-based systems were developed for the therapeutic delivery of natural antioxidants with improved bioavailability, solubility, stability, and efficacy. This study aimed to compare the antioxidant potential of gallic acid with its nanoniosome. Methods: For this purpose, nanoniosome (a mixture of gallic acid, Span 60, Tween 60, cholesterol and polyethylene glycol 4000) was prepared by thin layer hydration method. Then, antioxidant activity was evaluated using DPPH (2,2-diphenyl-1-picryl-hydrazine-hydrate) and ABTS [2,2 -azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] tests. Results and discussion: Based on DPPH results, gallic acid nanoniosomes (IC50: 86 mg/ml) showed significant antioxidant activity compared to gallic acid (IC50: 148mg/ml) in a time- and dose-dependent manner. But according to the ABTS method, no significant antioxidant activity was observed between them. Conclusion: It can be concluded that the nanoniosome delivery system improves the antioxidant potential of gallic acid, and it can be suggested in the food and medicinal industries.