پديدآورندگان :
Mirbagheri Zeinab Department of Chemical Engineering, Isfahan University of Technology , Mohammadzadeh Mahsa Department of Materials Engineering, Isfahan University of Technology , Fakhar Afsaneh a.fakhar@iut.ac.ir Department of Chemical Engineering, Isfahan University of Technology , Labbaf Sheyda Department of Materials Engineering, Isfahan University of Technology
كليدواژه :
Silver nanoparticles , In , situ synthesis , Silk fibroin , Nanocomposites , Antibacterial activity
چكيده فارسي :
Recently, nanotextiles with robust antibacterial capabilities has gained significant level of attention over the past few years. The necessity for durable antibacterial nanotextiles underscores the significance of this endeavor. The in-situ synthesis of nanoparticles within a polymer matrix represents a feasible and efficient approach to production of nanocomposites. This methodology facilitates the one-step fabrication of nanocomposites, with nanoparticles formed precisely within their intended locations within the polymer matrix. This approach maintains a well-dispersed distribution of nanoparticles while preventing particle aggregation. Nanoscale metals offer an expansive surface area relative to their non-nanoscale or bulk counterparts which includes unique physical and chemical properties such as increased surface area, small size, and quantum effects. In this regard, silver nanoparticles (AgNPs) have gained substantial attention due to their effective antibacterial properties to extent of inhibiting the growth and activity of both gram-positive and gram-negative bacteria. Silk fibroin (SF), a natural polymer, stands out as a promising biomaterial due to its biocompatibility, adjustable degradability, low toxicity, and mechanical resilience. This research introduces an innovative approach to address the challenge of producing antibacterial nanotextiles through the in-situ synthesis of silver nanoparticles directly within the silk fibroin polymer substrate, thereby creating a polymer nanocomposite. A key feature of this approach is the use of sodium borohydride (NaBH4) as a reducing agent, with silk fibroin serving as a stabilizing agent. An inherent advantage of this technique is the precise control it affords over nanoparticle distribution. A comprehensive analysis of the resulting AgNP-SF nanocomposites using a range of analytical methods, including UV-Vis spectroscopy, X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) has been performed. The UV-Vis spectrum yielded results confirming the successful synthesis of AgNPs, exhibiting a monodisperse distribution of nanoparticles with maximum absorption around 420 nm. FTIR analysis facilitated the identification of the chemical composition of the resultant nanocomposite, elucidating distinct functional groups and linkages. XRD analysis corroborated the presence of AgNPs and underscored the clarity of amorphous regions within the silk fibroin matrix. In summary, this research introduces an innovative method for synthesizing silk fibroin nanocomposites containing AgNPs, endowed with potent antibacterial properties. The results of this study highlights the potential of these nanocomposites as a safe and efficacious materials for medical and biological applications. A meticulous examination of the results and resulting properties underscores the potential of these nanocomposites as safe and efficacious materials for medical and biological applications. This study represents an essential progress towards the development of antibacterial nanotextiles, harnessing the intrinsic antibacterial activity of nanoparticles, particularly AgNPs.
