پديدآورندگان :
Hashemi Afzal Fariba f.hashemiafzal@modares.ac.ir Biotechnology Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran , Bagheri Fatemeh f.bagheri@modares.ac.ir Biotechnology Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran , Baghaban Eslaminejad Mohamadreza eslami@royaninstitute.org Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran , Vasheghani-Farahani Ebrahim evf@modaers.ac.ir Biomedical Engineering Division, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran , Azami Mahmoud m-azami@tums.ac.ir Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran , Tayebi Lobat lobat.tayebi@marquette.edu Department of Developmental Sciences, School of Dentistry, Marquette University Milwaukee, USA
كليدواژه :
electrospun nanofibers , silk fibroin (SF) , polyethylene Oxide (PEO) , polyvinyl Alcohol (PVA) , bone tissue engineering
چكيده فارسي :
This research paper investigates the effects of polyethylene oxide (PEO) and polyvinyl alcohol (PVA) on the morphology of electrospun silk fibroin (SF) nanofibers for bone tissue engineering applications. SF alone has limitations in electrospinning due to low viscosity and surface tension. The study aims to characterize the nanofiber morphology, diameter distribution, and cell adhesion of SF/PEO and SF/PVA blend nanofiber structures. Scanning electron microscopy (SEM) and cell attachment assays were employed for analysis. The results show that PEO incorporation improves uniformity and reduces diameter variation, enhancing cell adhesion. In contrast, PVA incorporation contributes to uniformity but leads to broader diameter distribution and lower cell adhesion compared to SF/PEO. These findings provide valuable insights for designing composite nanofiber scaffolds with tailored properties for tissue engineering applications.
