پديدآورندگان :
mohammadi Abbas Department of Chemistry, University of Isfahan, Isfahan 81746-73441, I.R. Iran , salehi negar Department of Chemistry, University of Isfahan, Isfahan 81746-73441, I.R. Iran , Beigi-Boroujeni saeed School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada Sur, Monterrey 2501, N. L., Mexico , maleki aziz Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139-56184 Iran , bochani shayesteh Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139-56184 Iran , alinezhad vajiheh Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139-56184 Iran
كليدواژه :
Tissue engineering , Antibacterial activity , Waterborne polyurethane , Wound dressing , Photothermal therapy
چكيده فارسي :
Photothermal therapy is a technique that converts light into heat energy to weaken the bacteria walls and thereby kill them. Combining photothermal therapy with traditional antibacterial agents such as AgNPs can combat bacterial infection more efficiently. Although silver is among the most studied traditional antibacterial agents, its accumulation and migration in the polymer matrix suppress its bactericidal performance. An appropriate substrate with a large surface area, such as graphene oxide (GO), can increase AgNP stability and address the mentioned problems. In this study, the AgNPs were in-situ decorated on the surface of graphene oxide using polydopamine (PDA). PDA served as a green reducing agent and a platform to attach the AgNPs on the surface of GO nanosheets. The Ag@PDA-GO hybrid nanostructures was incorporated into the WPU matrix to prepare antibacterial nanocomposite wound dressing with photothermal activity under NIR laser.
