شماره ركورد كنفرانس :
5536
عنوان مقاله :
PLA/NMP system containing silica hybrids for bone tissue engineering
پديدآورندگان :
Family Fereshteh fereshteh.family@aut.ac.ir Department of Polymer and Color Engineering, Amirkabir University of Technology, P.O. Box:15875-4413, Tehran, Iran , Mirzadeh Hamid Department of Polymer and Color Engineering, Amirkabir University of Technology, P.O. Box:15875-4413, Tehran, Iran , Bagheri-Khoulenjani Shadab Department of Polymer and Color Engineering, Amirkabir University of Technology, P.O. Box: 15875-4413, Tehran, Iran
كليدواژه :
tissue engineering , poly(lactic acid) , phase separation systems , biopolymer
عنوان كنفرانس :
پانزدهمين همايش بين المللي علوم و فناوري پليمر
چكيده فارسي :
In this study, an in situ forming (ISF) scaffold was investigated for the purpose of bone tissue engineering. Poly(lactic acid) (PLA) and N-methyl-2-pyrrolidone (NMP) based systems were prepared, and PLA chains were functionalized by an aminolysis treatment. The amine groups react with (3-Glycidyloxypropyl)trimethoxysilane (GPTMS), which is the coupling agent between the organic phase and silica network. The inorganic phase was prepared by sol-gel reaction using GPTMS and tetraethyl orthosilicate (TEOS). PLA-based systems were characterized using scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectra, and Ultraviolet-visible spectroscopy (UV-Vis). The results show that free amine groups ascent with HDA content and decrease with the formation of silica hybrids.
