شماره ركورد كنفرانس :
5536
عنوان مقاله :
Synthesis and characterization of thermosensitive gel containing PCL nanoparticles as a promising candidate for drug delivery
پديدآورندگان :
Nademi Naghmeh Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran , Mohseni Mojdeh mohsenimojdeh90@gmail.com 2 Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran /3 Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran , Najmoddin Najmeh najmoddin@srbiau.ac.ir Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
كليدواژه :
Nanoparticle , Drug delivery system , Hydrogel , Bone inflammation
عنوان كنفرانس :
پانزدهمين همايش بين المللي علوم و فناوري پليمر
چكيده فارسي :
In this study, a novel thermosensitive implant containing PCL nanoparticles has been synthesized as a possible candidate for drug delivery applications. Scanning electron microscopy (SEM) exhibited the spherical morphology of the nanoparticle and dynamic light scattering (DLS) showed the hydrodynamic diameter of 609 nm. Then, nanoparticles were incorporated into a gellan-based hydrogel with 1, 3, and 5) % w/v). A gelation time of 7 min was achieved for the optimum sample (3(%w/v)). Also, the swelling ratio of the optimum sample was found to be 11%, 13%, and 15% at different time points of 5, 10, and 15 min, respectively. Such a drug delivery system has a high potential to be used as a suitable carrier for bone inflammations.
