پديدآورندگان :
Mozafari Faezeh Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran , Ramazani Ali Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran , Tabatabaei Rezaei Seyed Jamal Laboratory of Novel Drug Delivery Systems, Department of Chemistry, University of Zanjan, Zanjan, Iran , Samadi Ali Department of Polymer Engineering, Faculty of Engineering, Urmia University, Urmia, Iran , Abdollahi Hossein H.Abdollahi@urmia.ac.ir Department of Polymer Engineering, Faculty of Engineering, Urmia University, Urmia, Iran , Rashidzadeh Hamid Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran/Laboratory of Novel Drug Delivery Systems, Department of Chemistry, University of Zanjan, Zanjan, Iran
كليدواژه :
Biomedicine , palmitic acid , MTT , acut toxicity , hemocompatibility
چكيده فارسي :
Recently, biodegradable polymers based on natural fatty acids have been extensively employed in the field of biomedicine. However, concerns remain with respect to their harmful effects. Current work was designed to disclose the biocompatibility of palmitic acid conjugated PEG (mPEG- palmitic acid) designed for biomedical application. Due to its amphiphilic feature, mPEG- palmitic acid easily undergoes self-assembly to form micelles in an aqueous media. A biocompatibility study indicated that mPEG- palmitic acid had no harmful effects on Artemia Salina since no mortality rate of nauplii was found, and the safety of mPEG- palmitic acid is thus underlined. In addition, at a high concentration of tested polymeric materials, only 3% hemolysis was observed and obviously prove the hemocompatibility of mPEG- palmitic acid. All treated mice survived, after receiving mPEG- palmitic acid through oral administration, and due to its safety, they can be used in biomedicine. MTT assay also confirms the biocompatibility of palmitic acid conjugated PEG. These results offer compelling evidence for the usefulness of mPEG- palmitic acid as a promising and nontoxic polymeric biomaterial for biomedical application.
