پديدآورندگان :
Habibi Younes Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran , Sadeghi Moslem Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran , Bohlool Tohid Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran , Nikfarjam Nasser Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran/Department of Chemical Engineering, College of Engineering and Computing, University of South Carolina,Columbia, Columbia, SC, USA. , Mohamadnia Zahra z.mohamadnia@iasbs.ac.ir Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran
كليدواژه :
Self , healing hydrogels , Host , guest , Antibacterial , β , cyclodextrin dimer
چكيده فارسي :
Self-healing hydrogels have potential applications in tissue engineering, drug delivery, and biomedicine. As a result, the construction and development of hydrogels that can repair damages and have suitable mechanical properties attracted much attention. Host-guest (HG) based self-healing hydrogels have poor mechanical properties. This challenge was mainly solved using β-cyclodextrin dimer (bis-CD) as host cross-linker and silver nitrate nanoparticles. For this purpose, alginate modified with dopamine (Alg-DA) and bis-CD as a guest polymer and host cross-linker was synthesized. Then, Alg-DA/bis-CD and Alg-DA/bis-CD/AgNO3 NPs hydrogels were constructed based on HG complexation. These hydrogels have favorable mechanical and self-healing properties (the mechanical strength of Alg-DA/Bis-CD hydrogel is 3490 Pa). Also, due to the presence of AgNO3 NPs, Alg-DA/bis-CD/AgNO3 NPs hydrogel showed good antibacterial properties. Biocompatibility, self-healing (in less than 10 seconds), and antibacterial properties of these hydrogels make them suitable options for wound dressings and coatings.
