پديدآورندگان :
Noorafkan Yasmin yasnoor75@gmail.com Isfahan university of technology, Isfahan, Iran/Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases, Research Institute, Tehran University of Medical Sciences, Tehran, Iran , Dorkhani Eefan School of Chemical Engineering, College of Engineering, University of Tehran, IranSchool of Chemical Engineering, College of Engineering, University of Tehran, Iran , Behzad Tayebeh Isfahan university of technology, Isfahan, Iran , Ghiassi Mohammad Adel Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran , Ahmadi Tafti Seyyed Hossein Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases, Research Institute, Tehran University of Medical Sciences, Tehran, Iran , Heirani-Tabasi Asieh Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
كليدواژه :
Cardiac tissue engineering , 3D bio printing , Electroconductive hydrogel scaffold , Alginate
چكيده فارسي :
Heart failure and myocardial infarction are significant reasons for worldwide mortality. Due to the high-cost surgery and the irreversible side effects, cardiac tissue engineering represented a novel approach by fabricating three-dimensional electro-conductive scaffolds as a treatment for this issue. Electroconductive hydrogel scaffolds are profitable platforms thanks to their 3D, highly hydrophilic structure providing electrical signal transmission among cardiac cells. Here, an electro-conductive hydrogel scaffold based on modified Alginate was fabricated via a 3D extrusion bioprinting method and investigated its potential for cardiac tissue engineering. The results revealed an enhancement in tensile modulus in a specific modification percentage. Cytotoxicity results also represented non-toxic and safe criteria with high cell density levels on the scaffold after seven days of mouse embryonic cardiomyocytes culture, indicating its productivity in cardiac tissue engineering.
