شماره ركورد كنفرانس
5536
عنوان مقاله
Fabrication and characterization of 3D bio-printed electroconductive hydrogel scaffold based on Alginate and its application in cardiac tissue engineering
پديدآورندگان
Noorafkan Yasmin yasnoor75@gmail.com Isfahan university of technology, Isfahan, Iran/Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases, Research Institute, Tehran University of Medical Sciences, Tehran, Iran , Dorkhani Eefan School of Chemical Engineering, College of Engineering, University of Tehran, IranSchool of Chemical Engineering, College of Engineering, University of Tehran, Iran , Behzad Tayebeh Isfahan university of technology, Isfahan, Iran , Ghiassi Mohammad Adel Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran , Ahmadi Tafti Seyyed Hossein Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases, Research Institute, Tehran University of Medical Sciences, Tehran, Iran , Heirani-Tabasi Asieh Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
تعداد صفحه
2
كليدواژه
Cardiac tissue engineering , 3D bio printing , Electroconductive hydrogel scaffold , Alginate
سال انتشار
1401
عنوان كنفرانس
پانزدهمين همايش بين المللي علوم و فناوري پليمر
زبان مدرك
انگليسي
چكيده فارسي
Heart failure and myocardial infarction are significant reasons for worldwide mortality. Due to the high-cost surgery and the irreversible side effects, cardiac tissue engineering represented a novel approach by fabricating three-dimensional electro-conductive scaffolds as a treatment for this issue. Electroconductive hydrogel scaffolds are profitable platforms thanks to their 3D, highly hydrophilic structure providing electrical signal transmission among cardiac cells. Here, an electro-conductive hydrogel scaffold based on modified Alginate was fabricated via a 3D extrusion bioprinting method and investigated its potential for cardiac tissue engineering. The results revealed an enhancement in tensile modulus in a specific modification percentage. Cytotoxicity results also represented non-toxic and safe criteria with high cell density levels on the scaffold after seven days of mouse embryonic cardiomyocytes culture, indicating its productivity in cardiac tissue engineering.
كشور
ايران
لينک به اين مدرک