Preparation and evaluation of antibacterial PVA/Gelatin/NIPU wound dressing membranes containing Guanidine hydrochloride moieties

The preparation of wound dressing membranes composed of polyvinyl alcohol (PVA) and gelatin crosslinked through the application of methoxysilane terminated nonisocyanate polyurethane (MSiNIPU) is described in the work. Also, in order to arm the wound dressings with antibacterial properties, polyhexamethylene guanidine (PHMG ) is introduced into formulations. Based on various in vitro tests, it is revealed that the prepared membranes have the basic characteristics of ideal dressings, while they can actively inhibit the growth and proliferation of bacterial strains.