Author/Authors
Larry W. Daniel، نويسنده , , Vicki A. Sciorra، نويسنده , , SujoyGhosh، نويسنده ,
DocumentNumber
1601463
Title Of Article
Phospholipase D, tumor promoters, proliferation and prostaglandins
شماره ركورد
11673
Latin Abstract
Phosphatidylcholine hydrolysis by phospholipase D is a widespread response to cellular stimulation. However, the downstream signaling events subsequent to phosphatidylcholine hydrolysis are just beginning to be determined. Initially it was proposed that diglyceride formation by phospholipase D and phosphatidatephosphohydrolase resulted in long-term stimulation of protein kinase C. However, recent studies indicate that phosphatidic acid is the relevant signaling molecule in some signaling pathways. The present review will summarize studies of phospholipase D in the response of cells to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, which causes cells to mimic the phenotype of oncogenic transformation. The role of phospholipase D in stimulation of Raf-1 and prostaglandin H synthase type-2 is emphasized.
From Page
265
NaturalLanguageKeyword
phospholipase d , Tumor promoter , Prostaglandin H synthase type 2 , Raf-1
JournalTitle
Studia Iranica
To Page
276
To Page
276
Link To Document