Author/Authors
Ewald H. Hettema، نويسنده , , Henk F. Tabak، نويسنده ,
DocumentNumber
1601611
Title Of Article
Transport of fatty acids and metabolites across the peroxisomal membrane
شماره ركورد
11915
Latin Abstract
The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid β-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. Genetic and biochemical studies in the yeast Saccharomyces cerevisiae have identified enzymes for redox shuttles as well as the first peroxisomal membrane transporter. This peroxisomal ATP-binding cassette transporter (Pat) is highly homologous to the gene mutated in X-linked adrenoleukodystrophy (X-ALD). The yeast Pat is required for import of activated fatty acids into peroxisomes suggesting that this is the primary defect in X-ALD.
From Page
18
NaturalLanguageKeyword
Carnitine palmitoyltransferase , fatty acid oxidation , Malonyl-CoA , Contact site , Porin , mitochondria
JournalTitle
Studia Iranica
To Page
27
To Page
27
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