مرکز منطقه ای اطلاع رساني علوم و فناوري

Abstract :

Innate immune system in fish consist of physical, cellular and humoral factors along with other cellular and humoral receptor molecules that can be dissolved in plasma and other body fluids. Cellular factors include cytotoxic cells that appear to be equivalent to natural killer cells in mammals, neutrophyl granulocytes and monocyte/macrophages as phagocytic cell. Macrophages which belong to above mentioned cells are indicator cells of innate immunity in fish and other vertebrates having phagocytic ability. Through which they posses functions like repairement after inflammation, tissue regeneration and elimination of old cells. Since melanomacrophage centers are pigmented, they can be easily identified from macrophages in histological examinations and they can also be widely observed in many organs in poikilothermic vertebrates. These centers are named as macrophage stocks, macrophage accumulation centres or pigmented nodules and considered as spesific cells in tissue of heterothermic vertebrates. In this rewiev, the system that these structures are belong to in fish and the cells and their units through which they communicate and functions are discussed.