Arslan, S Cumhuriyet Üniversitesi - Tıp Fakültesi - Göğüs Hastalıkları Anabilim Dalı, Turkey , Çelik, O Nihat Kitapçı Devlet Hastanesi - Göğüs Hastalıkları, Turkey , Baran, A Süreyyapasa Eğitim Hastanesi - Göğüs Hastalıkları, Turkey , Güngör, S Cizre Devlet Hastanesi - Göğüs Hastalıkları, Turkey , Akkaya, E Süreyyapasa Eğitim Hastanesi - Göğüs Hastalıkları, Turkey

The importance of serum markers to detect the activity of Sarcoidosis

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Aim: The aims of the present study were investigating the role of serum markers in estimating disease activity in sarcoidosis and determining the relationships between these markers.Material and Methods: The diagnosis of sarcoidosis was based on the clinical, radiological and hystopathological findings. The disease activity was determined according to the clinical and radiological findings and the results of pulmonary function tests. The levels of total ADA, ADA1, ADA2, ACE and IgE were determined in sera. The patients were divided into two groups according to the disease activity in year 1 and year 2.Results: There were no significant differences regarding mean serum levels of five markers between patients with active and inactive disease course. In patients with active disease course over last one year, there were significant correlations between serum levels of IgE-ADA1 and IgE-total ADA, ADA1-ADA2, and ADA1- total ADA. In patients with inactive disease course over last one year, there were significant correlations between serum levels of ADA1 -total ADA, ADA 2 - total ADA.Conclusion: Our findings suggest that there were no significant correlation between disease activity and serum levels of five markers in patients with sarcoidosis. However, our findings suggest that there are correlations between lymphocyte derived markers.

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Sarcoidosis , marker , activity

Ege Journal Of Medicine

48