مرکز منطقه ای اطلاع رساني علوم و فناوري - The effects of systolic- diastolic blood pressure, urine protein excretion and doppler findings on perinatal outcome in preeclamptic women

Abstract :

Aim : To evaluate the effects of maternal systolic- diastolic blood pressure at first admission, urine protein excretion and Doppler findings on perinatal outcome in preeclamptic women. Material and Methods: 196 preeclamptic women who admitted to the Ege University School of Medicine Obstetrics and Gynecology Clinic and hospitalized between January 2004 and December 2008 were investigated retrospectively. Investigations included blood pressure values at first admission, urine protein excretion, Doppler findings, intrauterine growth restriction, oligohydramnios and their effects on perinatal outcomes. 74 pregnancies with sufficient data were included in the study. The clinical correlations used in the study were gestational week at birth, birth weight, Doppler sonographic findings, urine protein values, 1 and 5 minute apgar scores, and amniotic fluid index. The SPSS 13.0 programme was used for statistical analysis. Varians analysis and Chi- square test were used for correlations and p 0.05 value was accepted as statistically significant.Results: The mean age of the pregnant women was 29.09 ± 5.52. Systolic blood pressure for 37 was (50%) ≥ 160 mm/Hg, and 6 had (8.1%) diastolic blood pressure at ≥ 110 mm/Hg. There were 17 (23%) whose urine protein excretion in 24 hours was between 300 mg- 1 gr; 18 (24%) had output between 1 gr- 2 gr and 39 (52.7%) had ≥ 2 gr. There were 42 pregnant women (56.8%) with normal Doppler findings, 28 (37.8%) with abnormal arterial system and 4 (5.4%) with abnormal venous system. There was a statistically significant correlation between high diastolic blood pressure and abnormal venous Doppler findings (p 0.05). High diastolic blood pressure was also correlated with oligohydramnios and birth weight (p 0.05). There was a statistically significant difference between the urine protein excretion ≥ 2 gr group and the 2 gr group in birth weights, birth weeks, as well as 1 and 5 minute apgar scores (p 0.05). Intrauterine growth restriction and oligohydraminos were significantly higher in the abnormal venous system group than the other (p 0.05) group. There was no difference in 1 and 5 minute apgar scores between the normal doppler group and the abnormal arterial system group (p 0.05), however, there was a statistically significant difference between the abnormal venous system group and the other two groups (p 0.05) Conclusion: Maternal diastolic blood pressure, urine protein values and doppler findings effect perinatal outcome.