Süleymanlar, İ Akdeniz Üniversitesi - Tıp Fakültesi - Gastroenteroloji, Turkey , Karataş, G U Akdeniz Üniversitesi - Tıp Fakültesi - Nefroloji, Turkey , Koçak, H Akdeniz Üniversitesi - Tıp Fakültesi - Nefroloji, Turkey , Tekinalp, G Akdeniz Üniversitesi - Tıp Fakültesi - Patoloji, Turkey , Süleymanlar, G Akdeniz Üniversitesi - Tıp Fakültesi - Nefroloji, Turkey

Possible correlations among viremia, genotypes and liver histology in HCV(+) hemodialysis patients

14633

Aim: The aim of this study was to address whether there were possible correlations between viral load or HCV genotype and clinicopathological features in hemodialysis patients with chronic HCV infection. Material and Methods: Seventy three HCV antibody (+) hemodialysis patients (Mean age: 47.3 ± 15.6 years, Male/Female: 40/33 ) were enrolled in the study. The biochemical, viral and histological data were analyzed retrospectively in these patients on dialysis (mean duration; 10.4±4.4 years).Results: ALT level was normal in 50 patients (68.5%), intermittently high in 18 patients (24.8%) and persistently high in 5 patients (6.8%). HCV RNA (57, 5 %) was positive in 42 of 73 patients. HCV genotype was determined in 29 patients. HCV genotype 1a was detected in three cases and HCV genotype 1b was detected in 26 patients. There was no difference between HCV RNA positive patients and HCV RNA negative ones with regard to age, gender, duration of dialysis, ALT and albumin levels. A liver biopsy was performed in 21 of 73 patients. It was found that histological features were not different between HCV RNA (+) and HCV RNA (-) patients. Moreover, HAI and fibrosis scores were found to be similar among patients with HCV genotype 1a, HCV genotype 1b and an undetermined genotype.Conclusion:Our results demonstrate that viral load or HCV genotype do not correlate with clinicopathological features in hemodialysis patients with chronic HCV infection. But further studies should be performed to clarify possible clinicopathologic correlations in HCV Ab (+) hemodialysis patients.

101

HCV RNA , HCV genotypes , liver injury , hemodia

Ege Journal Of Medicine

106