Author/Authors :
Karan, M A İstanbul Üniversitesi - Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Geriatri Bilim Dalı, Turkey , Tufan, F İstanbul Üniversitesi - İstanbul Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Geriatri Bilim Dalı, Turkey
Title Of Article :
Mechanisms of aging
Abstract :
Aging is caused by gradual accumulation of damage in cells and tissues. Accumulation of damage begins early and continues progressively throughout the life. These processes result in loss of adaptive response to stress, in growing risk of age-related diseases, and in the increase in the probability of dying, or age-specific death rate in the population. Much of the damage results from reactive oxygen species; these molecules arise as a side-effect of essential biochemical processes, like the utilization of oxygen to generate chemical energy through oxidative phosphorylation. Multiple genes regulate the efficacy of “longevity-assurance” processes such as DNA repair that together influence the rate of aging. However, some other factors, such as nutrition and environmental temperature, can have important effects in modulating the rate of the accumulation of damage within the body.
NaturalLanguageKeyword :
Aging , reactive oxygen species , genetic , nutrition
JournalTitle :
Ege Journal Of Medicine
