Kavukçu, G Ege Üniversitesi - Tıp Fakültesi - Radyoloji Anabilim Dalı, Turkey , Tamsel, S Ege Üniversitesi - Tıp Fakültesi - Radyoloji Anabilim Dalı, Turkey , Yılmaz, F Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Nart, D Ege Üniversitesi - Tıp Fakültesi - Tıbbi Patoloji Anabilim Dalı, Turkey , Zeytunlu, M Ege Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Turkey , Kılıç, M Ege Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Turkey

Hepatocellular carcinoma in cirrhotic liver: Accuracy of pretransplantation ultrasonography

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Aim: To assess the accuracy of ultrasonography in detecting hepatocellular carcinoma in patients with advanced cirrhosis undergoing liver transplantation.Materials and Methods: Four hundred ninety five patients, who underwent liver transplantation and had histopathologically proved liver cirrhosis, were included in the study. Reports of pretransplantation ultrasonography and histopathologic evaluation of the explanted liver were retrospectively reviewed and compared for the presence of hepatocellular carcinoma.Results: Hepatocellular carcinoma was detected in the explanted liver in 88 (17,8%) patients. The hepatomas ranged in size from 0.1 to 11cm. One or more solid focal lesions were reported in the pretransplant ultrasonography examination in 58 of these patients. In 16 patients, with a focal lesion reported in the pretransplant US examination, no hepatocellular carcinoma was detected in the histopathologic examination. The patient detection sensitivity of ultrasonography for hepatocellular carcinoma was 66%, specificity was 96%, the positive predictive value was 78% and negative predictive value was 93%. Conclusion: Sensitivity of utrasonography for hepatocellular carcinoma detection mostly depends on tumor size and is low in liver transplant candidates. On the other hand, the specificity is high and all solid lesions discovered with the ultrasonography should be considered hepatocellular carcinoma until proven otherwise.

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Liver , fibrosis , carcinoma , hepatocellular , screening , ultrasonography

Ege Journal Of Medicine

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