Yılmaz, F Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Günüşen, İ Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Çertuğ, A Ege Üniversitesi - Tıp Fakültesi - Anesteziyoloji ve Reanimasyon Anabilim Dalı, Turkey , Önen Sertöz, Ö Ege Üniversitesi - Tıp Fakültesi - Psikiyatri Anabilim Dalı, Turkey

The effect of dexmedetomidine on cognitive function and anxiety in middle-ear surgery

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Aim: Controlled hypotension has been used commonly during surgical procedures to reduce intraoperative hemorrhage. However, it can be detrimental to cognitive functions. This study is a prospective trial conducted to compare the effects of remifentanil alone and dexmedetomidine supplemented with remifentanil infusions on cognitive function and anxiety.Materials and Methods: Forty patients scheduled for tympanoplasty were allocated randomly into groups to receive either remifentanil (1μg kg^-1 loading; maintenance, 0.25-0.5 μg kg^-1 min^-1) or dexmedetomidine combined with remifentanil infusion (1 μg kg^-1 dexmedetomidine loading; maintenance, 0.5 μg kg^-1 h^-1 dexmedetomidine and 0.25-0.5 μg kg^-1 min^-1 remifentanil). Hemodynamic changes, opioid requirement, bleeding, recovery time, cognitive functions and anxiety scores were recorded.Results: Dexmedetomidine combined with remifentanil was found to have the same effect as remifentanil alone on hemodynamics. The remifentanil group was associated with significantly shorter recovery time. A mini-mental status test at 30 and 120 min and the Trieger dot test at 30 and 60 min in the remifentanil group were better than the other group whereas the Digit symbol substitution test and anxiety scores were similar in both postoperatively. The patients in the dexmedetomidine group had only lower anxiety scores postoperatively according to baseline values.Conclusion: Remifentanil was more advantageous in middle ear surgery as it was associated with a shorter recovery time and earlier recovery of cognitive functions compared with the dexmedetomidine group.

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Controlled hypotension , remifentanil , dexmedetomidine , cognitive function , anxiety

Ege Journal Of Medicine

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